Journal article
MAJOR MALFORMATIONS IN INFANTS OF IDDM WOMEN - VASCULOPATHY AND EARLY 1ST-TRIMESTER POOR GLYCEMIC CONTROL
M MIODOVNIK, F MIMOUNI, PS DIGNAN, MA BERK, JL BALLARD, TA SIDDIQI, J KHOURY, RC TSANG
DIABETES CARE | AMER DIABETES ASSOC | Published : 1988
Abstract
From animal and in vitro studies, it has been suggested that high environmental glucose, ketone, or insulin concentrations and low glucose or insulin concentrations may be etiologic factors for congenital malformations (CMs) in infants of diabetic mothers (IDMs). Transplacental passage of antibody-bound insulin has been demonstrated in humans. Controversy exists regarding the pathophysiology of CMs in human insulin-dependent diabetes mellitus (IDDM) pregnancies. We hypothesized that CMs in IDMs are associated with maternal vasculopathy, poor first-trimester glycemic control (i.e., hyper- and/or hypoglycemia), advanced White class, and high insulin requirements. We studied 165 first pregnanci..
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Awarded by NCRR NIH HHS
Awarded by NICHD NIH HHS