Placental creatine metabolism in cases of placental insufficiency and reduced fetal growth
Stacey J Ellery, Padma Murthi, Miranda L Davies-Tuck, Paul A Della Gatta, Anthony K May, Greg M Kowalski, Damien L Callahan, Clinton R Bruce, Nicole O Alers, Suzanne L Miller, Jan Jaap HM Erwich, Euan M Wallace, David W Walker, Hayley Dickinson, Rod J Snow
Molecular Human Reproduction | OXFORD UNIV PRESS | Published : 2019
Creatine is a metabolite involved in cellular energy homeostasis. In this study, we examined placental creatine content, and expression of the enzymes required for creatine synthesis, transport and the creatine kinase reaction, in pregnancies complicated by low birthweight. We studied first trimester chorionic villus biopsies (CVBs) of small for gestational age (SGA) and appropriately grown infants (AGA), along with third trimester placental samples from fetal growth restricted (FGR) and healthy gestation-matched controls. Placental creatine and creatine precursor (guanidinoacetate-GAA) levels were measured. Maternal and cord serum from control and FGR pregnancies were also analyzed for crea..View full abstract
National Health and Medical Research Council (NHMRC) (to H.D., D.W. and R.S.) and the Victorian Government Infrastructure Support Fund to the Hudson Institute of Medical Research.