Journal article

Depressive psychopathology in first-episode schizophrenia spectrum disorders: a systematic review, meta-analysis and meta-regression

Sarah E Herniman, Kelly Allott, Lisa J Phillips, Stephen J Wood, Jacqueline Uren, Sumudu R Mallawaarachchi, Sue M Cotton

Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2019

Abstract

BACKGROUND: Despite knowing for many decades that depressive psychopathology is common in first-episode schizophrenia spectrum disorders (FES), there is limited knowledge regarding the extent and nature of such psychopathology (degree of comorbidity, caseness, severity) and its demographic, clinical, functional and treatment correlates. This study aimed to determine the pooled prevalence of depressive disorder and caseness, and the pooled mean severity of depressive symptoms, as well as the demographic, illness, functional and treatment correlates of depressive psychopathology in FES. METHODS: This systematic review, meta-analysis and meta-regression was prospectively registered (CRD42018084..

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Grants

Awarded by National Health and Medical Research Council


Awarded by NHMRC


Funding Acknowledgements

SEH is supported by a Research Training Program Scholarship awarded by the Australian Commonwealth Government. SMC is supported by a National Health and Medical Research Council Senior Research Fellowship (APP1136344). KA is supported by a Career Development Fellowship from the NHMRC (1141207).