Journal article

Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism

AE Shindler, EL Hill-Yardin, S Petrovski, N Bishop, AE Franks

Journal of Autism and Developmental Disorders | SPRINGER/PLENUM PUBLISHERS | Published : 2020


This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate statistical significance for the Prolactin (PRL) (OR 6.35, p value 0.069) and Interleukin 10 (IL-10) (OR 0.25, p value 0.087) SNPs. The GI dysfunction group had a strong statistical significance for the Cluster of Differentiation 38 (CD38) (OR 6.88, p value 0.005) and oxytocin receptor (OXTR) (OR 0.27, p value 0.036) SNPs. The potential use of PRL, IL-10, C..

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