Incidence, Risk Factors, and Outcomes of Cancer in Systemic Sclerosis
Kathleen Morrisroe, Dylan Hansen, Molla Huq, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Nava Ferdowsi, Catherine Hill, Janet Roddy, Jennifer Walker, Susanna Proudman, Mandana Nikpour
Arthritis Care & Research | WILEY | Published : 2020
OBJECTIVE: To quantify the burden of cancer in systemic sclerosis (SSc). METHODS: Standardized incidence ratios (SIRs) and standardized mortality ratios relative to the general Australian population were derived. Cox proportional hazards regression was used to estimate survival in patients with SSc with cancer compared to patients without. Determinants of cancer were identified using logistic regression. Health care cost was quantified through cross-jurisdictional data linkage. RESULTS: This SSc cohort of 1,727 had a cancer incidence of 1.3% per year and a prevalence of 14.2%, with a SIR of 2.15 (95% confidence interval [95% CI] 1.84-2.49). The most common cancers were breast, melanoma, hema..View full abstract
Awarded by National Health and Medical Research Council of Australia Career Development Fellowship
Supported by Scleroderma Australia, Arthritis Australia, Actelion Australia, Bayer, CSL Biotherapies, GlaxoSmithKline Australia, and Pfizer. Dr. Morrisroe's work was supported by Arthritis Australia and the Royal Australasian College of Physicians DEV Star Research Establishment Fellowships. Dr. Nikpour's work was supported by a National Health and Medical Research Council of Australia Career Development Fellowship (APP 1126370).