Maternal intramuscular dexamethasone versus betamethasone before preterm birth (ASTEROID): a multicentre, double-blind, randomised controlled trial
Caroline A Crowther, Pat Ashwood, Chad C Andersen, Philippa F Middleton, Tran Thach, Lex W Doyle, Jeffrey S Robinson, Jane E Harding, Vincent Ball, Carol Holst, Kaye Robinson, Sasha Zhang, Yee Khong, Andrew McPhee, Katie Groom, Jane Alsweiler, Deb Eaglen, Helga Hauch, Alenna Vallely, Sonia Angus Show all
LANCET CHILD & ADOLESCENT HEALTH | ELSEVIER SCI LTD | Published : 2019
BACKGROUND: Antenatal corticosteroids given to women before preterm birth improve infant survival and health. However, whether dexamethasone or betamethasone have better maternal, neonatal, and childhood health outcomes remains unclear. We therefore aimed to assess whether administration of antenatal dexamethasone to women at risk of preterm birth reduced the risk of death or neurosensory disability in their children at age 2 years compared with betamethasone. We also aimed to assess whether dexamethasone reduced neonatal morbidity, had benefits for the mother, or affected childhood body size, blood pressure, behaviour, or general health compared with betamethasone. METHODS: In this multicen..View full abstract
National Health and Medical Research Council (Australia).