Journal article

Diagnosis and management of Guillain-Barre syndrome in ten steps

Sonja E Leonhard, Melissa R Mandarakas, Francisco AA Gondim, Kathleen Bateman, Maria LB Ferreira, David R Cornblath, Pieter A van Doorn, Mario E Dourado, Richard AC Hughes, Badrul Islam, Susumu Kusunoki, Carlos A Pardo, Ricardo Reisin, James J Sejvar, Nortina Shahrizaila, Cristiane Soares, Thirugnanam Umapathi, Yuzhong Wang, Eppie M Yiu, Hugh J Willison Show all

NATURE REVIEWS NEUROLOGY | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The gu..

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Grants

Awarded by European Union


Awarded by Ministry of Education, Culture, Sports, Science and Technology of Japan


Awarded by Malaysian Ministry of Education


Funding Acknowledgements

The authors thank Lisa Butler (Executive Director, GBS/CIDP Foundation International) for her contribution in reviewing the manuscript. C.A.P., C.S., M.L.B.F., M.R.M., and S.E.L. are supported by a grant from the European Union (Horizon 2020, ZikaPLAN Grant Agreement No. 734584). H.J.W. is supported by a grant from the European Union (Horizon 2020, ZikaPLAN Grant Agreement No. 734584) and by the Wellcome Trust Foundation. B.C.J. is supported by a grant from the European Union (Horizon 2020, ZikaPLAN Grant Agreement No. 734584) and has received funding from Prinses Beatrix Spierfonds and GBS/CIDP Foundation International. F.d.A.A.G. is supported by a grant from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico. D.R.C. is on the Board of Directors for the Peripheral Nerve Society. P.A.v.D. received a grant from the Prinses Beatrix Foundation for the SID-GBS randomized controlled trial. S.K. is supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Grants-in-Aid for Scientific Research, 18H02745) and the Ministry of Health, Labour and Welfare of Japan (Health and Labour Sciences Research Grant). N.S. is supported by grants from the Malaysian Ministry of Education (FP043-2018A) and ALS Association. T.U. is supported by a grant from the GBS/CIDP Foundation International. E.M.Y. is supported by a grant from the National Health and Medical Research Council of Australia (Early Career Fellowship).