Journal article

Cytarabine-based induction immunochemotherapy in the front-line treatment of older patients with mantle cell lymphoma

Sumita Ratnasingam, Joshua Casan, Jake Shortt, Eliza Hawkes, Michael Gilbertson, Zoe McQuilten, George Grigoriadis, Kay Thwe Htun, Swe Myo Htet, Philip Campbell, Khai Li Chai, Hang Quach, Sushrut Patil, Stephen Opat

Scientific Reports | Nature Publishing Group | Published : 2019

Abstract

The role of cytarabine-based induction and autologous stem cell transplantation (ASCT) in front-line treatment of younger patients with mantle cell lymphoma (MCL) is well established, however the utility of intensive approaches in older patients remains unclear. This retrospective study compared first line treatment outcomes in patients aged 60 years or more, treated at six tertiary centres between 2000-2015. 70 patients included had a median age of 69 (60-91) and most (94%) demonstrated advanced stage disease. Treatment regimens included: R-CHOP-like (n = 39), alternating R-CHOP/R-DHAC (n = 10), R-HyperCVAD/R-MA (n = 7), R-CHOP/Cytarabine (Nordic Protocol) (n = 10) and other (n = 4). 16 pat..

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