Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)

Abstract

Abstract Nations throughout the Indo-Pacific region use pyrethroid insecticides to control Aedes aegypti , the mosquito vector of dengue, often without knowledge of pyrethroid resistance status of the pest or origin of resistance. Two mutations in the sodium channel gene ( Vssc ) of Ae. aegypti modify ion channel function and cause target-site resistance to pyrethroid insecticides, with a third mutation having a potential additive effect. Of 27 possible genotypes involving these mutations, some allelic combinations are never seen while others predominate. Here, five common combinations in Ae. aegypti from the Indo-Pacific region are described and tracked historically through genomic analyses..