Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

C Yung; TM MacDonald; SP Walker; P Cannon; A Harper; N Pritchard; NJ Hannan; TJ Kaitu'u-Lino; S Tong

Journal article

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

C Yung, TM MacDonald, SP Walker, P Cannon, A Harper, N Pritchard, NJ Hannan, TJ Kaitu'u-Lino, S Tong

Placenta | W B SAUNDERS CO LTD | Published : 2019

DOI: 10.1016/j.placenta.2019.09.010

Abstract

Introduction: Death associated protein kinase-1 (DAPK-1) is highly expressed in the placenta relative to all other human tissues. We examine whether it is differentially expressed with preeclampsia. Methods: We examined samples from a large prospective collection of plasma from 2002 women. We split the samples into two cohorts: Cohort 1 (n = 1000) and Cohort 2 (n = 1002). We first measured circulating DAPK-1 at 36 weeks' gestation in a nested case-control group (from Cohort 1) of 39 women who developed preeclampsia and 98 controls. We then validated our findings by measuring circulating levels in all samples from both cohorts. We also measured DAPK-1 in the circulation and placentas of women..

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University of Melbourne Researchers

Teresa MacDonald Author

Susan Walker Author

Ping Cannon Author

Alesia Harper Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding for this work was provided by the National Health and Medical Research Council (#1065854), Foresight Health, The Stillbirth Foundation and the Norman Beischer Medical Research Foundation; Australian Government Research Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to TM; National Health and Medical Research Council Fellowships to TKL (#1159261), ST (#1136418), NJH (#1146128). The funders had no role in the study.