Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia
Cameron Yung, Teresa M MacDonald, Susan P Walker, Ping Cannon, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong
PLACENTA | W B SAUNDERS CO LTD | Published : 2019
INTRODUCTION: Death associated protein kinase-1 (DAPK-1) is highly expressed in the placenta relative to all other human tissues. We examine whether it is differentially expressed with preeclampsia. METHODS: We examined samples from a large prospective collection of plasma from 2002 women. We split the samples into two cohorts: Cohort 1 (n = 1000) and Cohort 2 (n = 1002). We first measured circulating DAPK-1 at 36 weeks' gestation in a nested case-control group (from Cohort 1) of 39 women who developed preeclampsia and 98 controls. We then validated our findings by measuring circulating levels in all samples from both cohorts. We also measured DAPK-1 in the circulation and placentas of women..View full abstract
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Awarded by National Health and Medical Research Council
Funding for this work was provided by the National Health and Medical Research Council (#1065854), Foresight Health, The Stillbirth Foundation and the Norman Beischer Medical Research Foundation; Australian Government Research Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to TM; National Health and Medical Research Council Fellowships to TKL (#1159261), ST (#1136418), NJH (#1146128). The funders had no role in the study.