Expression of Programmed Cell Death-Ligands in Hepatocellular Carcinoma: Correlation With Immune Microenvironment and Survival Outcomes
Haotian Liao, Wen Chen, Yunlu Dai, Joseph J Richardson, Junling Guo, Kefei Yuan, Yong Zeng, Kunlin Xie
Frontiers in Oncology | FRONTIERS MEDIA SA | Published : 2019
The quantity of programmed cell death-ligand 1 (PD-L1) is regarded as a predicting factor of clinical response to anti-PD-1 axis immunotherapy. However, the expression of PD-L1 and its prognostic value in hepatocellular carcinoma (HCC) patients remain debated. Meanwhile, the molecular features of PD-1's other ligand, namely PD-L2, as well as its correlation with clinicopathological parameters and HCC tumor microenvironment (TME), are still poorly understood. In this study, immunohistochemistry (IHC) data from 304 HCC patients were used to determine the clinicopathological features of PD-L1 and PD-L2 and their correlation with CD8+ T cells in HCC. Moreover, fresh clinical HCC samples were use..View full abstract
Awarded by Natural Science Foundation of China
Awarded by Science and Technology Support Program of Sichuan Province
This work was supported by grants from the Natural Science Foundation of China (81872004, 81800564, 81770615, 81700555, 81672882, and 81502441) and the Science and Technology Support Program of Sichuan Province (2017SZ0003, 2018SZ0115).