Journal article

Expression of Programmed Cell Death-Ligands in Hepatocellular Carcinoma: Correlation With Immune Microenvironment and Survival Outcomes

Haotian Liao, Wen Chen, Yunlu Dai, Joseph J Richardson, Junling Guo, Kefei Yuan, Yong Zeng, Kunlin Xie

FRONTIERS IN ONCOLOGY | FRONTIERS MEDIA SA | Published : 2019

Abstract

The quantity of programmed cell death-ligand 1 (PD-L1) is regarded as a predicting factor of clinical response to anti-PD-1 axis immunotherapy. However, the expression of PD-L1 and its prognostic value in hepatocellular carcinoma (HCC) patients remain debated. Meanwhile, the molecular features of PD-1's other ligand, namely PD-L2, as well as its correlation with clinicopathological parameters and HCC tumor microenvironment (TME), are still poorly understood. In this study, immunohistochemistry (IHC) data from 304 HCC patients were used to determine the clinicopathological features of PD-L1 and PD-L2 and their correlation with CD8+ T cells in HCC. Moreover, fresh clinical HCC samples were use..

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University of Melbourne Researchers

Grants

Awarded by Natural Science Foundation of China


Awarded by Science and Technology Support Program of Sichuan Province


Funding Acknowledgements

This work was supported by grants from the Natural Science Foundation of China (81872004, 81800564, 81770615, 81700555, 81672882, and 81502441) and the Science and Technology Support Program of Sichuan Province (2017SZ0003, 2018SZ0115).