Journal article

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon Show all

Cancer Cell | CELL PRESS | Published : 2019

Grants

Awarded by Cancer Research UK Clinician Scientist Fellowship


Awarded by Howard Hughes Medical Institute International Research Scholarship


Awarded by Wellcome Trust Principal Research Fellowship


Awarded by Maddie Riewoldt's Vision


Awarded by National Breast Cancer Foundation Fellowship


Awarded by NHMRC


Funding Acknowledgements

We thank the Peter MacCallum Cancer Center Molecular Genomics Core and the flow cytometry facilities at the Peter MacCallum Cancer Center and Cambridge Institute for Medical Research. We thank Andrew Flies and Jocelyn Darby (University of Tasmania) for the DFT cells. We thank the following funders for fellowship, scholarship, and grant support: Cancer Research UK Clinician Scientist Fellowship C53779/A20097 (to M.L.B.), Leukaemia Foundation Australia Senior Fellowship and Howard Hughes Medical Institute International Research Scholarship 55008729 (to M.A.D.), Peter and Julie Alston Centenary fellowship (to K.D.S.), Wellcome Trust Principal Research Fellowship 101835/Z/13/Z (to P.J.L.), Peter MacCallum Postgraduate Scholarship (to C.E.S.), NHMRC Postgraduate Scholarship (to K.L.C.), Maddie Riewoldt's Vision 064728 (to Y.-C.C.), Victorian Cancer Agency (to E.Y.N.L.), CSL Centenary fellowship (to S.-J.D.), National Breast Cancer Foundation Fellowship ECF17-005 (to P.A.B.), Addenbrooke's Charitable Trust and NIHR Cambridge BRC (to M.L.B. and P.J.L.), NHMRC grants 1085015, 1106444 (to M.A.D) and 1128984 (to M.A.D. and S.-J.D.).