Impact of Granulocyte-colony Stimulating Factor on Bleomycin-induced Pneumonitis in Chemotherapy-treated Germ Cell Tumors

Abstract

The impact of granulocyte-colony stimulating factor use on bleomycin-induced pneumonitis in patients with germ cell tumor is not clearly defined. This analysis of over 200 patients with germ cell tumor treated with bleomycin-containing chemotherapy found no association between the use of granulocyte-colony stimulating factor, and the incidence or severity of bleomycin-induced pneumonitis. The decision to use growth factor support in this population should continue to be individualized. Objective: To examine the impact of granulocyte-colony stimulating factor (G-CSF) use on the incidence and severity of bleomycin-induced pneumonitis (BIP) in patients with germ cell tumor (GCT) receiving first..