Journal article
Folate levels in pregnancy and offspring food allergy and eczema
J Molloy, F Collier, R Saffery, KJ Allen, JJ Koplin, A Louise Ponsonby, MLK Tang, AC Ward, D Martino, D Burgner, JB Carlin, S Ranganathan, C Symeonedies, T Dwyer, P Vuillermin
Pediatric Allergy and Immunology | WILEY | Published : 2020
DOI: 10.1111/pai.13128
Abstract
Background: High folate status in pregnancy has been implicated in the increased prevalence of allergic disease, but there are no published data relating directly measured folate status in pregnancy to challenge-proven food allergy among offspring. The study aim was to examine the association between red blood cell (RBC) folate status in trimester three of pregnancy and allergic disease among offspring. Methods: Red blood cell folate levels were measured at 28-32 weeks’ gestation in a prospective birth cohort (n = 1074). Food allergy outcomes were assessed in 1-year-old infants by skin prick testing and subsequent food challenge. Eczema was assessed by questionnaire and clinical review. High..
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Funding Acknowledgements
The establishment work and infrastructure for the BIS was provided by the Murdoch Childrens Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation and GMHBA. Support in kind has been provided by The Cotton On Foundation and CreativeForce.