Using subjective cognitive decline to identify high global amyloid in community-based samples: A cross-cohort study.

Rachel F Buckley; Sietske Sikkes; Victor L Villemagne; Elizabeth C Mormino; Jennifer S Rabin; Samantha Burnham; Kathryn V Papp; Vincent Doré; Colin L Masters; Michael J Properzi; Aaron P Schultz; Keith A Johnson; Dorene M Rentz; Reisa A Sperling; Rebecca E Amariglio

Journal article

Using subjective cognitive decline to identify high global amyloid in community-based samples: A cross-cohort study.

Rachel F Buckley, Sietske Sikkes, Victor L Villemagne, Elizabeth C Mormino, Jennifer S Rabin, Samantha Burnham, Kathryn V Papp, Vincent Doré, Colin L Masters, Michael J Properzi, Aaron P Schultz, Keith A Johnson, Dorene M Rentz, Reisa A Sperling, Rebecca E Amariglio

Alzheimers Dement (Amst) | Published : 2019

DOI: 10.1016/j.dadm.2019.08.004

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Abstract

Introduction: We aimed to examine the contribution of subjective cognitive decline (SCD) to reduce the number of β-amyloid (Aβ) positron emission tomography scans required for recruiting Aβ+ clinically normal individuals in clinical trials. Methods: Three independent cohorts (890 clinically normal: 72 yrs ± 6.7; Female: 43.4%; SCD+: 24%; apolipoprotein E [APOE] ε4+: 28.5%; Aβ+: 32%) were used. SCD was dichotomized from one question. Using logistic regression, we classified Aβ+ using the SCD dichotomy, APOEε4, sex, and age. Results: SCD increased odds of Aβ+ by 1.58 relative to non-SCD. Female APOEε4 carriers with SCD exhibited higher odds of Aβ+ (OR = 3.34), whereas male carriers with SCD sh..

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