Journal article

Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat

Werner I Furuya, Rishi R Dhingra, Andrew L Gundlach, Mohammad Akhter Hossain, Mathias Dutschmann

Respiratory Physiology & Neurobiology | ELSEVIER | Published : 2020

Abstract

The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal and cognitive processes via activation of the relaxin-family peptide 3 receptor (RXFP3). Despite the presence of RXFP3 in the nucleus of the solitary tract (NTS), the ability of RXFP3 to modulate NTS-mediated cardiorespiratory functions has not been explored. Therefore, we examined the effects of bilateral microinjections of the selective agonist, RXFP3-A2 (40 μM, 100 nL/side), into the NTS in perfused working-heart-brainstem-preparations from rats (n = 6), while recording phrenic, vagal, and thoracic sympathetic chain activity (PNA, VNA, t-SCA) and heart rate (H..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by NHMRC (Australia)


Funding Acknowledgements

This study was supported by an Australian Research Council (ARC) Future Fellowship to MD and ARC Discovery Grant (DP170104861) to MD. Peptide chemistry was partially supported by NHMRC (Australia) project grants (1023321 and 1023078) to MAH.We acknowledge financial support from the Victorian State Government Infrastructure Program to The Florey Institute of Neuroscience and Mental Health.