Journal article

Universal Panel Testing of Pancreatic Cancer Cases for Cancer Predisposition

Erin Young, Bryony Thompson, Deborah Neklason, Angela Snow, Matthew Firpo, Theresa Werner, Russell Bell, Nykole Sutherland, Ken Smith, Justin Berger, Alison Fraser, Amanda Gammon, Cathryn Koptiuch, Wendy Kohlmann, Leigh Neumayer, David Goldgar, Sean Mulvihill, Lisa Cannon-Albright, Sean Tavtigian

Published : 2017


ABSTRACT Background and Aims Genes associated with hereditary breast and ovarian cancer (HBOC) and colorectal cancer (CRC) susceptibility have been shown to play a role in pancreatic cancer susceptibility. Germline genetic testing of pancreatic cancer cases could be beneficial for at-risk relatives with pathogenic variants in established HBOC and CRC genes, but it is unclear what proportion of pancreatic cancer cases harbor pathogenic variants in these genes. Methods 66 pancreatic cancer cases, unselected for family history and diagnosed at the Huntsman Cancer Hospital (HCH), were sequenced on a custom 34-gene panel including known HBOC and CRC genes. A second set of 156 unselected HCH pancr..

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University of Melbourne Researchers


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