Journal article

Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era

Lex William Doyle, Louis Irving, Anjali Haikerwal, Katherine Lee, Sarath Ranganathan, Jeanie Cheong

Thorax | BMJ PUBLISHING GROUP | Published : 2019

Abstract

BACKGROUND: It is unknown if adults born <28 weeks or <1000 g since surfactant has been available are reaching their full airway growth potential. OBJECTIVE: To compare expiratory airflow at 25 years and from 8 to 25 years of participants born <28 weeks or <1000 g with controls, and within the preterm group to compare those who had bronchopulmonary dysplasia with those who did not. METHODS: All survivors born <28 weeks or 2499 g. At 8, 18 and 25 years, expiratory airflows were measured and the results converted to z-scores. Outcomes were compared between groups at age 25 years, and trajectories (change in z-scores per year) from childhood were contrasted between groups. RESULTS: Expiratory a..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council of Australia (Centre of Clinical Research Excellence)


Awarded by National Health and Medical Research Council of Australia (Centre of Research Excellence)


Awarded by National Health and Medical Research Council of Australia (Career Development Fellowship)


Funding Acknowledgements

Grants from the National Health and Medical Research Council of Australia (Program Grant #606789; Project Grant #491246; Centre of Clinical Research Excellence #546519; Centre of Research Excellence #1060733; Centre of Research Excellence #1153176; Project Grant #1104300; Career Development Fellowship #1141354 to JC and #1127984 to KL) and Operational Infrastructure Support Program from the state government of Victoria.