Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish
Grace E Lidgerwood, Alex W Hewitt, Alice Pebay
Current Opinion in Pharmacology | ELSEVIER SCI LTD | Published : 2019
Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation and modelling have relied on two-dimensional monocultures of specific cell types, which are not representative of the complexity of the human retina and optic nerve. Hence, more complex models of the human retina and optic nerve are required. Three-dimensional organoids and emerging cell culture methods may provide more physiologically relevant models to study developmental biolog..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by ARC Training Centre for Personalised Therapeutics Technologies
This work was supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (1154389, AP), grants from the Macular Disease Foundation of Australia, the jack Brockhoff Foundation, the Therapeutics Technologies Research Initiative University of Melbourne, Stem Cells Australia - the Australian Research Council (ARC) Special Research Initiative in Stem Cell Science and the ARC Training Centre for Personalised Therapeutics Technologies (IC170100016) and funded by the Australian Government, the JEM Research Foundation, the TMG Family Fund, the University of Melbourne and Operational Infrastructure Support from the Victorian Government.