Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target
Rebecca M Christoff, Chamodi K Gardhi, Tatiana P Soares da Costa, Matthew A Perugini, Belinda M Abbott
RSC Medicinal Chemistry | ROYAL SOC CHEMISTRY | Published : 2019
Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The development of inhibitors of the enzyme dihydrodipicolinate synthase (DHDPS), which is involved in the diaminopimelate pathway, represents an attractive approach to the discovery of new antibacterial agents. Herein, the challenges and opportunities of DHDPS inhibitors are discussed.
Awarded by Australian National Health and Medical Research Council
We are very grateful for the ongoing support and many helpful chemical discussions provided by Dr. Les Deady. R. M. C. would like to acknowledge the Australian Government as a recipient of an Australian Government Research Training Program Scholarship and the assistance provided by a LIMS Write-Up Award. C. K. G. would like to acknowledge La Trobe University as a recipient of La Trobe University Postgraduate Research Scholarship and La Trobe University Full Fee Research Scholarship. T. P. S. C. acknowledges support from an Australian National Health and Medical Research Council Early Career Fellowship (APP1091976).