Journal article

Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

Rebecca M Christoff, Chamodi K Gardhi, Tatiana P Soares da Costa, Matthew A Perugini, Belinda M Abbott

MEDCHEMCOMM | ROYAL SOC CHEMISTRY | Published : 2019

Abstract

Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The development of inhibitors of the enzyme dihydrodipicolinate synthase (DHDPS), which is involved in the diaminopimelate pathway, represents an attractive approach to the discovery of new antibacterial agents. Herein, the challenges and opportunities of DHDPS inhibitors are discussed.

University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

We are very grateful for the ongoing support and many helpful chemical discussions provided by Dr. Les Deady. R. M. C. would like to acknowledge the Australian Government as a recipient of an Australian Government Research Training Program Scholarship and the assistance provided by a LIMS Write-Up Award. C. K. G. would like to acknowledge La Trobe University as a recipient of La Trobe University Postgraduate Research Scholarship and La Trobe University Full Fee Research Scholarship. T. P. S. C. acknowledges support from an Australian National Health and Medical Research Council Early Career Fellowship (APP1091976).