Journal article

Early clinical markers of overweight/obesity onset and resolution by adolescence

Markus Juonala, Ted Lau, Melissa Wake, Anneke Grobler, Jessica A Kerr, Costan G Magnussen, Matthew A Sabin, David P Burgner, Kate Lycett

International Journal of Obesity | NATURE PUBLISHING GROUP | Published : 2020

Abstract

OBJECTIVES: We examined how combinations of clinical indicators at various ages predict overweight/obesity development, as well as resolution, by 10-11 and 14-15 years of age. METHODS: Data were derived from Birth (N = 3469) and Kinder (N = 3276) cohorts of the Longitudinal Study of Australian Children, followed from ages 2-3 and 4-5 years, respectively. Every two years, 25 potential obesity-relevant clinical indicators were quantified. Overweight/obesity was defined using International Obesity Taskforce cutpoints at 10-11 years and 14-15 years. RESULTS: In both cohorts, three factors predicted both development and resolution of overweight/obesity in multivariable models. Among normal weight..

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Grants

Awarded by NHMRC Senior Research Fellowship


Awarded by National Heart Foundation of Australia Future Leader Fellowship


Awarded by Honorary Future Leader Fellowship of the National Heart Foundation of Australia


Awarded by NHMRC Early Career Fellowship


Awarded by Honorary National Heart Foundation of Australia Postdoctoral Fellowship


Funding Acknowledgements

Prof. MJ was supported by Juho Vainio Foundation and federal research grants to Turku University Hospital. Prof. MW was supported by NHMRC Senior Research Fellowship 1046518 and Cure Kids New Zealand. Dr Magnussen is supported by a National Heart Foundation of Australia Future Leader Fellowship (100849). Prof. DB is supported by NHMRC Senior Research Fellowship 1064629 and an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (100369). Dr KL was supported by NHMRC Early Career Fellowship (1091124) and Honorary National Heart Foundation of Australia Postdoctoral Fellowship (101239). Research at the Murdoch Childrens Research Institute research is supported by the Victorian Government's Operational Infrastructure Program. The funding bodies did not play any role in the study.