Journal article

The Utility of the Congenital Pulmonary Airway Malformation-Volume Ratio in the Assessment of Fetal Echogenic Lung Lesions: A Systematic Review

Stefan C Kane, Emanuele Ancona, Karen L Reidy, Ricardo Palma-Dias

Fetal Diagnosis and Therapy | KARGER | Published : 2020


Although relatively uncommon, the incidence of fetal echogenic lung lesions - a heterogeneous group of anomalies that includes congenital pulmonary airway malformations (CPAM) and bronchopulmonary sequestrations (BPS) - has increased recently. Two decades ago, the CPAM-volume ratio (CVR) was first described as a tool to predict the development of hydrops, with this outcome found to be unlikely in fetuses with CVRs of ≤1.6 cm2. Since then, no clear international consensus has evolved as to the optimal CVR thresholds for the prediction of fetal/neonatal outcomes. This systematic review aimed to assess all original research studies that reported on the predictive utility of the CVR. Potentially..

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Funding Acknowledgements

S.C.K. is supported by an Australian Government Research Training Program Scholarship, and by a Postgraduate Scholarship from the Australian National Health and Medical Research Council. His PhD project is supported by grants from the Research Foundation of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, and from the Australasian Society for Ultrasound in Medicine. No funding body had direct involvement in the preparation or approval of the manuscript.