Journal article
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
B Neumann, R Baror, C Zhao, M Segel, S Dietmann, KS Rawji, S Foerster, CR McClain, K Chalut, P van Wijngaarden, RJM Franklin
Cell Stem Cell | Published : 2019
Abstract
Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, which can be reversed both in vitro and in vivo by calorie restriction (CR) and the CR mimetic metformin.
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Grants
Awarded by M.S.I. Foundation
Funding Acknowledgements
This work was supported by funding from the UK Multiple Sclerosis Society, MedImmune, The Adelson Medical Research Foundation, and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. P.v.W. was supported by the National Health and Medical Research Council of Australia (ECF #628928). We thank Dr. Daniel Morrison for assistance with electron microscopy, the NIHR Cambridge BRC Cell Phenotyping Hub for all flow cytometry work, and the staff at the Cambridge Advanced Imaging Centre.