Journal article
Kidney organoids: Accurate models or fortunate accidents
MH Little, AN Combes
Genes and Development | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2019
Abstract
There are now many reports of human kidney organoids generated via the directed differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of mammalian kidney organogenesis. Such kidney organoids potentially represent tractable tools for the study of normal human development and disease with improvements in scale, structure, and functional maturation potentially providing future options for renal regeneration. The utility of such organotypic models, however, will ultimately be determined by their developmental accuracy. While initially inferred from mouse models, recent transcriptional analyses of human fetal kidney have provided greater insight into nephrogene..
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Awarded by National Institutes of Health
Funding Acknowledgements
We thank Jessica Vanslambrouck, Sara Howden, Kynan Lawlor, Lorna Hale, Julie Moreau, Sean Wilson, Ker Sin Tan, Lakshi Starks, Shahnaz Khan, Belinda Phipson, Luke Zappia from the Murdoch Childrens Research Institute, Tomoyo Miyashi and Ryuji Morizane from Brigham andWomen's Hospital, Kimberley Homan, Navin Gupta and Jennifer Lewis from Harvard University and Benjamin Freedman and Nelly Cruz from University of Washington for the provision of images. M.H.L. is a Senior Principal Research Fellow of the National Health and Medical Research Council of Australia (GNT1136085). MHL and A.N.C. receive funding from the NHMRC (GNT1156567) in the area of kidney development. A.N.C. receives funding from the Australian Research Council (DP190101037). M.H.L. receives funding from the National Health and Medical Research Council (GNT1100970, GNT1098654) and the National Institutes of Health (DK107344-02) for research into kidney organoids.