Journal article

IgM in human immunity to Plasmodium falciparum malaria

MJ Boyle, JA Chan, I Handayuni, L Reiling, G Feng, A Hilton, L Kurtovic, D Oyong, KA Piera, BE Barber, T William, DP Eisen, G Minigo, C Langer, DR Drew, F de Labastida Rivera, FH Amante, TN Williams, S Kinyanjui, K Marsh Show all

SCIENCE ADVANCES | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019

Abstract

Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in Plasmodium falciparum infection and is prominent during malaria in children and adults with lifetime exposure, together with IgG. Unexpectedly, IgM persisted for extended periods of time; we found no difference in decay of merozoite-specific IgM over time compared to that of IgG. IgM blocked merozoite inv..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) [program grants and senior research fellowships to J.G.B., I.M., D.L.D., J.S.M., C.E., and N.M.A.; and project grant, early career fellowship to M.J.B. (GTN 1125656) and B.E.B., and career development award to M.J.B. (GTN 1141632)]; the Australian Research Council (future fellowships to F.J.I.F.); the Channel 7 Children's Research Foundation (grant to M.J.B. and G.M.); the Australian Centre of Research Excellence in Malaria Elimination, NHMRC (to N.M.A., J.G.B.,, I.M., J.S.M., and F.J.I.F.); and the Wellcome Trust UK (to T.N.W., S.K., K.M., and J.G.B.). The Burnet Institute is supported by the NHMRC for Independent Research Institutes Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Support.