Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes
Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K Thompson, Alexei A Kouzmitchev, Hayley E Bullen, Paul R Gilson, Alan F Cowman, Christopher J Tonkin
mBio | AMER SOC MICROBIOLOGY | Published : 2019
Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial therapeutics that target the asexual cycle and the symptomatic stage of malaria. Host cell entry is enabled by a multitude of precisely timed and tightly regulated receptor-ligand interactions. Cyclic nucleotide signaling has been implicated in regulating parasite invasion, and an important downstream effector of the cAMP-signaling pathway is protein kinase A (PKA), a cAMP-dependent protein kinase. There is increasing evidence that P. falciparum PKA (PfPKA) is responsible for phosphorylation of the cytoplasmic domain of P. falciparum apical membrane antigen 1 (PfA..View full abstract
M.-L.W. is a recipient of a Research Training Program Scholarship, and A.F.C. is a NHMRC Senior Principal Research Fellow. We also acknowledge an Australian Research Council Future Fellowship awarded to C.J.T. We are also grateful for institutional support from the Victorian State Government operational infrastructure and the Australian Government (NHMRC IRIISS).