Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems
Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2019
Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel antiarrhythmic therapies are required to overcome current drug limitations related to effectiveness and pro-arrhythmia risk in some contexts. Cardiomyocyte culture models provide a high-throughput platform for screening antiarrhythmic compounds, but comparative information about electrophysiological properties of commonly used types of cardiomyocyte preparations is lacking. Standardization of cultured cardiomyocyte microelectrode array (MEA) experimentation is required for its application as a high-throughput platform for antiarrhythmic drug development. The aim of this study w..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Australian Research Council
This research was supported by the National Health and Medical Research Council (nos. 1099352 and 1125453; L. M. D. Delbridge, J. R. Bell) and the Australian Research Council (no. DP160102404; L. M. D. Delbridge).