Journal article

Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems

Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell

American Journal of Physiology-Cell Physiology | AMER PHYSIOLOGICAL SOC | Published : 2019

Abstract

Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel anti-arrhythmic therapies are required to overcome current drug limitations related to effectiveness and pro-arrhythmia risk in some contexts. Cardiomyocyte culture models provide a high-throughput platform forscreening anti-arrhythmic compounds, but comparative information about electrophysiological properties of commonly used types of cardiomyocyte preparations is lacking.Standardization of cultured cardiomyocyte microelectrode array (MEA) experimentation is required for its application as a high-throughput platform for anti-arrhythmic drug development. The aim of this study ..

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