Journal article

Hyper transmission of Beijing lineage Mycobacterium tuberculosis: Systematic review and meta-analysis

Malancha Karmakar, James M Trauer, David B Ascher, Justin T Denholm

Journal of Infection | W B SAUNDERS CO LTD | Published : 2019

Abstract

OBJECTIVES: The globally distributed "Beijing" lineage of Mycobacterium tuberculosis has been associated with outbreaks worldwide. Laboratory based studies have suggested that Beijing lineage may have increased fitness; however, it has not been established whether these differences are of epidemiological significance with regards to transmission. Therefore, we undertook a systematic review of epidemiological studies of tuberculosis clustering to compare the transmission dynamics of Beijing lineages versus the non-Beijing lineages. METHODS: We systematically searched Embase and MEDLINE before 31st December 2018, for studies which provided information on the transmission dynamics of the differ..

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Grants

Funding Acknowledgements

M.K was funded by the Melbourne Research Scholarship and supported in part by the Victorian Government's OIS Program. JTD receives funding from the Medical Research Future Fund and the National Health and Medical Research Council.