T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction
Chongshan Dai, Xilong Xiao, Feifei Sun, Yuan Zhang, Daniel Hoyer, Jianzhong Shen, Shusheng Tang, Tony Velkov
Archives of Toxicology | SPRINGER HEIDELBERG | Published : 2019
Mycotoxins are highly diverse secondary metabolites produced in nature by a wide variety of fungi. Mycotoxins cause animal feed and food contamination, resulting in mycotoxicosis. T-2 toxin is one of the most common and toxic trichothecene mycotoxins. For the last decade, it has garnered considerable attention due to its potent neurotoxicity. Worryingly, T-2 toxin can cross the blood-brain barrier and accumulate in the central nervous system (CNS) to cause neurotoxicity. This review covers the current knowledge base on the molecular mechanisms of T-2 toxin-induced oxidative stress and mitochondrial dysfunction in the CNS. In vitro and animal data have shown that induction of reactive oxygen ..View full abstract
Awarded by Key Projects in Chinese National Science and Technology Pillar Program during the 12th Five-Year Plan Period
Awarded by National Key Research and Development Program of China
S.T. and X.X. were supported by the Key Projects in Chinese National Science and Technology Pillar Program during the 12th Five-Year Plan Period (No. 2015BAD11B03) and the National Key Research and Development Program of China (Project No. 2018YFC1603005).