Journal article

Effect of Corticosteroid-Sparing Treatment With Mycophenolate Mofetil vs Methotrexate on Inflammation in Patients With Uveitis: A Randomized Clinical Trial

SR Rathinam, John A Gonzales, Radhika Thundikandy, Anuradha Kanakath, S Bala Murugan, R Vedhanayaki, Lyndell L Lim, Eric B Suhler, Hassan A Al-Dhibi, Thuy Doan, Jeremy D Keenan, Maya M Rao, Caleb D Ebert, Hieu H Nguyen, Eric Kim, Travis C Porco, Nisha R Acharya

JAMA | AMER MEDICAL ASSOC | Published : 2019

Abstract

Importance: Methotrexate and mycophenolate mofetil are commonly used immunomodulatory therapies for achieving corticosteroid-sparing control of noninfectious uveitis, but there is uncertainty about which drug is more effective. Objective: To compare the effect of methotrexate and mycophenolate for achieving corticosteroid-sparing control of noninfectious intermediate uveitis, posterior uveitis, and panuveitis. Design, Setting, and Participants: The First-line Antimetabolites as Steroid-sparing Treatment (FAST) uveitis trial screened 265 adults with noninfectious uveitis requiring corticosteroid-sparing immunosuppressive therapy from 9 referral eye centers in India, the United States, Austral..

View full abstract

Grants

Awarded by NEI


Awarded by Research to Prevent Blindness Foundation from the NEI


Awarded by NATIONAL EYE INSTITUTE


Funding Acknowledgements

This study was supported by NEI cooperative agreement U10 EY021125 (to Dr Acharya, primary investigator). The University of California San Francisco pharmacy provided study drugs for all sites. The Department of Ophthalmology at UCSF is supported by an unrestricted grant from the Research to Prevent Blindness Foundation, a core grant (EY06190) from the NEI, and That Man May See Foundation.