Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis

Ayedh Alqarni; Todd W Mitchell; Patrick D McGorry; Barnaby Nelson; Connie Markulev; Hok Pan Yuen; Miriam R Schafer; Maximus Berger; Nilufar Mossaheb; Monika Schlogelhofer; Stephan Smesny; Ian B Hickie; Gregor E Berger; Eric YH Chen; Lieuwe de Haan; Dorien H Nieman; Merete Nordentoft; Anita Riecher-Rossler; Swapna Verma; Andrew Thompson; Alison Ruth Yung; Barbara J Meyer; G Paul Amminger

Journal article

Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis

Ayedh Alqarni, Todd W Mitchell, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stephan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Andrew Thompson Show all

SCHIZOPHRENIA RESEARCH | ELSEVIER | Published : 2020

DOI: 10.1016/j.schres.2019.08.033

Abstract

Omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) are necessary for optimum mental health, with recent studies showing low n-3 LCPUFA in people at ultra-high risk (UHR) of developing psychosis. Furthermore, people at UHR of psychosis had increased erythrocyte sphingomyelin (SM) and reduced phosphatidylethanolamine (PE) concentrations as well as 27 erythrocyte phospholipid species that differed when compared to erythrocytes from age matched people not at UHR of psychosis. The aim of this analysis was to evaluate the effect of n-3 supplementation on the different erythrocyte lipid species (including SM and PE concentrations) in people at UHR of psychosis. Participants were randomly a..

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University of Melbourne Researchers

Hok Yuen Author Centre for Youth Mental Health

Maximus Berger Author Centre for Youth Mental Health

Paul Amminger Author Centre for Youth Mental Health

Connie Markulev Author Centre for Youth Mental Health

Andrew Thompson Author Centre for Youth Mental Health

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Grants

Awarded by Stanley Medical Research Institute

Awarded by NHMRC Australia Program

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Awarded by NHMRC Career Development Fellowship

Awarded by ARC Future Fellowship

Funding Acknowledgements

This work was supported by grant 07TGF-1102 from the Stanley Medical Research Institute, grant 566529 from the NHMRC Australia Program (Drs McGorry, Hickie, and Yung, and Amminger), and a grant from the Colonial Foundation. Dr. McGorry was supported by Senior Principal Research Fellowship 1060996 from the National Health and Medical Research Council of Australia (NHMRC); Drs Yung and Amminger were supported by NHMRC Senior Research Fellowships 1080963 and 566593, respectively; and Dr. Nelson was supported by NHMRC Career Development Fellowship 1027532. This research was also supported by a small grant from the Faculty of Science, Medicine and Health, University of Wollongong. TWM was supported by an ARC Future Fellowship FT110100249. The authors would like to thank the volunteers that participated in this study. We also thank King Fahad Specialist Hospital administration, Dammam, Saudi Arabia for sponsoring Ayedh Alqarni.