Conference Proceedings
Smoking is associated with risks of molecular subtypes of colorectal cancer
Xiaoliang Wang, Efrat Amitay, Barbara L Banbury, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Jenny Chang-Claude, Steven J Gallinger, Graham G Giles, Tabitha A Harrison, John L Hopper, Mark A Jenkins, Yi Lin, Reiko Nishihara, Polly A Newcomb, Shuji Ogino, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Steven N Thibodeau Show all
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2019
Abstract
Abstract Background: Smoking has been associated with colorectal cancer (CRC) risk; but limited evidence has shown the association between smoking and molecular subtypes of CRC. Methods: We analyzed 9,422 CRC cases and 9,950 controls from 10 observational studies. Multinomial logistic regression analysis was performed to assess the association between sex-study-specific quartiles of pack years of smoking and risk of CRC molecular subtypes, using non-smokers as reference group, adjusting for age, sex, and study. Known oncogenic mutations in four somatic colorectal tumor markers were assessed individually and in combination, including BRAF mutations, KRAS mu..
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