Postnatal probiotics and allergic disease in very preterm infants: Sub-study to the ProPrems randomized trial
Erica L Plummer, Adriana Chebar Lozinsky, Jacinta M Tobin, Jessica B Uebergang, Christine Axelrad, Suzanne M Garland, Susan E Jacobs, Mimi LK Tang, SM Garland, SE Jacobs, JM Tobin, SN Tabrizi, M Pirotta, S Donath, GF Opie, MLK Tang, D Isaacs, NJ Evans, JM Kaldor, LW Doyle Show all
Allergy | WILEY | Published : 2019
BACKGROUND: Probiotic supplementation to mothers and/or their term-born infants has been suggested to prevent allergic disease, in particular eczema; however, no studies have investigated probiotics for prevention of allergic diseases in very preterm infants. We evaluated the effect of a postnatal probiotic combination on development of allergic diseases in very preterm infants. METHODS: This sub-study was an a priori secondary outcome of the ProPrems multi-center, double-blind, placebo-controlled randomized trial (ANZCTR:12607000144415). ProPrems randomized 1099 very preterm infants to receive a probiotic combination or placebo from soon after birth until discharge from hospital or term cor..View full abstract
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Awarded by National Health and Medical Research Council of Australia
National Health and Medical Research Council of Australia (project grant 454629), The Royal Women's Hospital Foundation, Melbourne, Australia, and The Angior Family Foundation, Melbourne, Australia. The Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.