Journal article

Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing

Travis K Johnson, Tova Crossman, Karyn A Foote, Michelle A Henstridge, Melissa J Saligari, Lauren Forbes Beadle, Anabel Herr, James C Whisstock, Coral G Warr

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2013

Abstract

Activation of the Drosophila receptor tyrosine kinase Torso (Tor) only at the termini of the embryo is achieved by the localized expression of the maternal gene Torso-like (Tsl). Tor has a second function in the prothoracic gland as the receptor for prothoracicotropic hormone (PTTH) that initiates metamorphosis. Consistent with the function of Tor in this tissue, Tsl also localizes to the prothoracic gland and influences developmental timing. Despite these commonalities, in our studies of Tsl we unexpectedly found that tsl and tor have opposing effects on body size; tsl null mutants are smaller than normal, rather than larger as would be expected if the PTTH/Tor pathway was disrupted. We fur..

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University of Melbourne Researchers

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Funding Acknowledgements

We thank James Heaney and the Australian Drosophila Biomedical Research Facility (OzDros) for technical support; Jordi Casanova for providing the N-terminally tagged Tsl construct; Marc Freeman, Peter Dearden, and Richard Burke for discussions; and two anonymous reviewers for their valuable feedback. This work was supported by the National Health and Medical Research Council of Australia (NHMRC), the Australian Research Council (ARC), and an Interdisciplinary Research Grant from Monash University. J.C.W. is an ARC Federation Fellow and an honorary NHMRC Principal Research Fellow.