Journal article

Interval breast cancer risk associations with breast density, family history and breast tissue aging

Tuong L Nguyen, Shuai Li, Gillian S Dite, Ye K Aung, Christopher F Evans, Ho N Trinh, Laura Baglietto, Jennifer Stone, Yun-Mi Song, Joohon Sung, Dallas R English, Mark A Jenkins, Pierre-Antoine Dugue, Roger L Milne, Melissa C Southey, Graham G Giles, Malcolm C Pike, John L Hopper



Interval breast cancers (those diagnosed between recommended mammography screens) generally have poorer outcomes and are more common among women with dense breasts. We aimed to develop a risk model for interval breast cancer. We conducted a nested case-control study within the Melbourne Collaborative Cohort Study involving 168 interval breast cancer patients and 498 matched control subjects. We measured breast density using the CUMULUS software. We recorded first-degree family history by questionnaire, measured body mass index (BMI) and calculated age-adjusted breast tissue aging, a novel measure of exposure to estrogen and progesterone based on the Pike model. We fitted conditional logistic..

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Awarded by Australian National Health and Medical Research Council

Awarded by Cure Cancer Australia - Cancer Australia

Awarded by US National Institutes of Health/National Cancer Institute Cancer Institute

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

Grant sponsor: Australian National Health and Medical Research Council; Grant numbers: 1074383, 209057, 251533, 396414, 504711; Grant sponsor: Cure Cancer Australia - Cancer Australia; Grant number: 1159399; Grant sponsor: US National Institutes of Health/National Cancer Institute Cancer Institute; Grant number: P30CA008748