Interval breast cancer risk associations with breast density, family history and breast tissue aging

Tuong L Nguyen; Shuai Li; Gillian S Dite; Ye K Aung; Christopher F Evans; Ho N Trinh; Laura Baglietto; Jennifer Stone; Yun-Mi Song; Joohon Sung; Dallas R English; Mark A Jenkins; Pierre-Antoine Dugue; Roger L Milne; Melissa C Southey; Graham G Giles; Malcolm C Pike; John L Hopper

Journal article

Interval breast cancer risk associations with breast density, family history and breast tissue aging

Tuong L Nguyen, Shuai Li, Gillian S Dite, Ye K Aung, Christopher F Evans, Ho N Trinh, Laura Baglietto, Jennifer Stone, Yun-Mi Song, Joohon Sung, Dallas R English, Mark A Jenkins, Pierre-Antoine Dugue, Roger L Milne, Melissa C Southey, Graham G Giles, Malcolm C Pike, John L Hopper

INTERNATIONAL JOURNAL OF CANCER | WILEY | Published : 2019

DOI: 10.1002/ijc.32731

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Abstract

Interval breast cancers (those diagnosed between recommended mammography screens) generally have poorer outcomes and are more common among women with dense breasts. We aimed to develop a risk model for interval breast cancer. We conducted a nested case-control study within the Melbourne Collaborative Cohort Study involving 168 interval breast cancer patients and 498 matched control subjects. We measured breast density using the CUMULUS software. We recorded first-degree family history by questionnaire, measured body mass index (BMI) and calculated age-adjusted breast tissue aging, a novel measure of exposure to estrogen and progesterone based on the Pike model. We fitted conditional logistic..

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University of Melbourne Researchers

Graham Giles Author Melbourne School of Population and Global Health

Shuai Li Author Melbourne School of Population and Global Health

Laura Baglietto Author Melbourne School of Population and Global Health

Kevin Nguyen Author Melbourne School of Population and Global Health

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Grants

Awarded by Australian National Health and Medical Research Council

Awarded by Cure Cancer Australia - Cancer Australia

Awarded by US National Institutes of Health/National Cancer Institute Cancer Institute

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

Grant sponsor: Australian National Health and Medical Research Council; Grant numbers: 1074383, 209057, 251533, 396414, 504711; Grant sponsor: Cure Cancer Australia - Cancer Australia; Grant number: 1159399; Grant sponsor: US National Institutes of Health/National Cancer Institute Cancer Institute; Grant number: P30CA008748