Journal article

Perspectives on Analytical Treatment Interruptions in People Living with HIV and Their Health Care Providers in the Landscape of HIV Cure-Focused Studies

Jillian SY Lau, Miranda Z Smith, Brent Allan, Cipriano Martinez, Jennifer Power, Sharon R Lewin, James H McMahon

AIDS Research and Human Retroviruses | MARY ANN LIEBERT, INC | Published : 2019

Abstract

BACKGROUND: Analytical treatment interruptions (ATI) aim to assess effects of HIV cure focused interventions, but poses potential risks. Understanding of ATI acceptability amongst people living with HIV (PLHIV) and their HIV healthcare providers (HHP) is limited. METHODS: Two international online surveys for PLHIV and HHP assessed understanding and acceptability of monitoring strategies during ATI. Survey items included: frequency of CD4, viral load (VL) and clinical assessment, CD4 and VL threshold to restart ART, acceptability of detectable viremia during ATI and potential risks of ATI. Responses were collected from July 2017-January 2018, and a descriptive analysis was performed. Response..

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Grants

Awarded by NHMRC


Awarded by National Institutes of Health Delaney AIDS Research Enterprise


Awarded by American Foundation for AIDS Research


Funding Acknowledgements

The institution of James H. McMahon and Jillian S.Y. Lau receive funding from Gilead Sciences, ViiV Healthcare, Merck, and Shire to conduct clinical trials. Jillian S.Y. Lau has an NHMRC Postgraduate Scholarship (1151607). James H. McMahon has an NHMRC Early Career Fellowship (1111099). Sharon R. Lewin is an NHMRC Practitioner Fellow (1042654) and is supported by the National Institutes of Health Delaney AIDS Research Enterprise (UM1 AI12661101) and the American Foundation for AIDS Research (109226-58 RGRL).