Histoplasmosis and multicentric lymphoma in a Nubian goat.
Samantha N Schlemmer, Alycia P Fratzke, Philippa Gibbons, Brian F Porter, Joanne Mansell, Richard J Ploeg, Aline Rodrigues Hoffmann, Caitlin E Older, Sabrina D Clark
J Vet Diagn Invest | Published : 2019
Following treatment for pneumonia, a 1-y-old female Nubian goat was presented because of a persistent fever for 3 mo and peripheral lymphadenopathy for 1 mo. Cytology and histology of the superficial cervical and prefemoral lymph nodes demonstrated a moderate-to-marked "left-shifted" lymphoid population, suggestive of lymphoma, and extremely rare extracellular, 2-4 µm, oval, basophilic yeast, consistent with Histoplasma capsulatum. On immunohistochemistry, >95% of the lymphocytes demonstrated positive cytoplasmic and membranous immunoreactivity for CD3. Histoplasma spp. urine antigen and serum antibody testing were positive and negative, respectively. Panfungal PCR and sequencing of DNA extr..View full abstract