Journal article

Histoplasmosis and multicentric lymphoma in a Nubian goat.

Samantha N Schlemmer, Alycia P Fratzke, Philippa Gibbons, Brian F Porter, Joanne Mansell, Richard J Ploeg, Aline Rodrigues Hoffmann, Caitlin E Older, Sabrina D Clark

J Vet Diagn Invest | Published : 2019

Abstract

Following treatment for pneumonia, a 1-y-old female Nubian goat was presented because of a persistent fever for 3 mo and peripheral lymphadenopathy for 1 mo. Cytology and histology of the superficial cervical and prefemoral lymph nodes demonstrated a moderate-to-marked "left-shifted" lymphoid population, suggestive of lymphoma, and extremely rare extracellular, 2-4 µm, oval, basophilic yeast, consistent with Histoplasma capsulatum. On immunohistochemistry, >95% of the lymphocytes demonstrated positive cytoplasmic and membranous immunoreactivity for CD3. Histoplasma spp. urine antigen and serum antibody testing were positive and negative, respectively. Panfungal PCR and sequencing of DNA extr..

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University of Melbourne Researchers