Journal article

Plasma ACE2 Activity Predicts Mortality in Aortic Stenosis and Is Associated With Severe Myocardial Fibrosis

Jay Ramchand, Sheila K Patel, Leighton G Kearney, George Matalanis, Omar Farouque, Piyush M Srivastava, Louise M Burrell



OBJECTIVES: This study investigated the relationship between plasma angiotensin-converting enzyme 2 (ACE2) activity levels and the severity of stenosis and myocardial remodeling in patients with aortic stenosis (AS) and determined if plasma ACE2 levels offered incremental prognostic usefulness to predict all-cause mortality. BACKGROUND: ACE2 is an integral membrane protein that degrades angiotensin II and has an emerging role as a circulating biomarker of cardiovascular disease. METHODS: Plasma ACE2 activity was measured in 127 patients with AS; a subgroup had myocardial tissue collected at the time of aortic valve replacement. RESULTS: The median plasma ACE2 activity was 34.0 pmol/ml/min, a..

View full abstract


Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council Program Grant (APP1055214) to Dr. Burrell. Dr. Ramchand is supported by a postgraduate scholarship co-funded by the National Heart Foundation of Australia and National Health and Medical Research Council (APP1132717). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.