Gastric Band Surgery Leads to Improved Insulin Secretion in Overweight People with Type 2 Diabetes
John M Wentworth, Julie Playfair, Cheryl Laurie, Wendy A Brown, Paul Burton, Jonathan E Shaw, Paul E O'Brien
Obesity Surgery | SPRINGER | Published : 2015
BACKGROUND: We aimed to determine the effects of laparoscopic adjustable gastric band (LAGB) on beta-cell function in overweight people with type 2 diabetes and to assess the relationship between baseline beta-cell function and glycemic outcomes. METHODS: We studied 44 overweight but not obese people with type 2 diabetes who participated in a randomized trial whose primary outcome was the rate of diabetes remission after 2 years of multidisciplinary diabetes care (MDC group) or multidisciplinary care combined with LAGB. Dynamic beta-cell function was assessed by intravenous glucose challenge, and basal beta-cell function (HOMA-B) and insulin sensitivity (HOMA-S) were determined using the hom..View full abstract
Awarded by National Health and Medical Research Council Fellowship
We are grateful to the participants for their commitment to this study and to Professor Glenn Ward and Dr. Matt Ritchie for helpful discussion. Maria Bisignano performed glucose, insulin, and C-peptide assays. This study was funded by the Center for Obesity Research and Education (CORE), Monash University. CORE receives grants from the Allergan and Applied Medical for research and educational support. The grants are not tied to any specified research projects, and the grantors have no control over the protocol, analysis, and reporting of any studies. Allergan donated the lap-band prostheses used in this study. The work was also supported by Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. JES is supported by a National Health and Medical Research Council Fellowship (586623).