Structure and Metal Binding Properties of Chlamydia trachomatis YtgA
Zhenyao Luo, Stephanie L Neville, Rebecca Campbell, Jacqueline R Morey, Shruti Menon, Mark Thomas, Bart A Eijkelkamp, Miranda P Ween, Wilhelmina M Huston, Bostjan Kobe, Christopher A McDevitt
JOURNAL OF BACTERIOLOGY | AMER SOC MICROBIOLOGY | Published : 2020
The obligate intracellular pathogen Chlamydia trachomatis is a globally significant cause of sexually transmitted bacterial infections and the leading etiological agent of preventable blindness. The first-row transition metal iron (Fe) plays critical roles in chlamydial cell biology, and acquisition of this nutrient is essential for the survival and virulence of the pathogen. Nevertheless, how C. trachomatis acquires Fe from host cells is not well understood, since it lacks genes encoding known siderophore biosynthetic pathways, receptors for host Fe storage proteins, and the Fe acquisition machinery common to many bacteria. Recent studies have suggested that C. trachomatis directly acquires..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Australian Research Council (ARC)
This study was supported by National Health and Medical Research Council (NHMRC) Program Grant 1071659 to B.K. and Project Grant 1122582 to C.A.M. and Australian Research Council (ARC) Discovery Project Grant DP170102102 to C.A.M. S.L.N. is an NHMRC Early Career Research Fellow (1142695), B.K. is an NHMRC Principal Research Fellow (1110971) and ARC Laureate Fellow (FL180100109), and C.A.M. is an ARC Future Fellow (FT170100006).