Journal article

Associations with Corneal Hysteresis in a Population Cohort Results from 96 010 UK Biobank Participants

Bing Zhang, Yusrah Shweikh, Anthony P Khawaja, John Gallacher, Sarah Bauermeister, Paul J Foster, Tariq Aslam, Sarah A Barman, Jenny H Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O Carare, Usha Chakravarthy, Michelle Chan, Sharon YL Chua, David P Crabb, Philippa M Cumberland, Alexander Day, Parul Desai Show all

Ophthalmology | ELSEVIER SCIENCE INC | Published : 2019

Abstract

PURPOSE: To describe the distribution of corneal hysteresis (CH) in a large cohort and explore its associated factors and possible clinical applications. DESIGN: Cross-sectional study within the UK Biobank, a large cohort study in the United Kingdom. PARTICIPANTS: We analyzed CH data from 93 345 eligible participants in the UK Biobank cohort, aged 40 to 69 years. METHODS: All analyses were performed using left eye data. Linear regression models were used to evaluate associations between CH and demographic, lifestyle, ocular, and systemic variables. Piecewise logistic regression models were used to explore the relationship between self-reported glaucoma and CH. MAIN OUTCOME MEASURES: Corneal ..

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Grants

Awarded by Medical Research Council, UK (MRC)


Funding Acknowledgements

This analysis was funded by the Medical Research Council, UK (MRC), through a grant to Dementia Platforms UK (DPUK) -MRC grant ref MR/L023784/2 (to B.Z.). Data from UK Biobank were accessed under application number 15008 (to B.Z.) on the DPUK Data Portal. The UK Biobank Eye and Vision Consortium is supported by grants from The National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, the Alcon Research Institute, Moorfields Eye Charity, and the International Glaucoma Association. No funders had a direct role in the collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or in the decision to submit the manuscript for publication.