Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

Andrea R Waksmunski; Michelle Grunin; Tyler G Kinzy; Robert P Igo; Jonathan L Haines; Jessica N Cooke Bailey; Lars G Fritsche; Wilmar Igl; Felix Grassmann; Sebanti Sengupta; Jennifer L Bragg-Gresham; Kathryn P Burdon; Scott J Hebbring; Cindy Wen; Mathias Gorski; Ivana K Kim; David Cho; Donald Zack; Eric Souied; Hendrik PN Scholl; Elisa Bala; Kristine E Lee; David J Hunter; Rebecca J Sardell; Paul Mitchell; Joanna E Merriam; Valentina Cipriani; Joshua D Hoffman; Tina Schick; Yara TE Lechanteur; Robyn H Guymer; Matthew P Johnson; Yingda Jiang; Chloe M Stanton; Gabrielle HS Buitendijk; Xiaowei Zhan; Alan M Kwong; Alexis Boleda; Matthew Brooks; Linn Gieser; Rinki Ratnapriya; Kari E Branham; Johanna R Foerster; John R Heckenlively; Mohammad Othman; Brendan J Vote; Helena Hai Liang; Emmanuelle Souzeau; Ian L McAllister; Timothy Isaacs; Janette Hall; Stewart Lake; David A Mackey; Ian J Constable; Jamie E Craig; Terrie E Kitchner; Zhenglin Yang; Zhiguang Su; Hongrong Luo; Daniel Chen; Hong Ouyang; Ken Flagg; Danni Lin; Guanping Mao; Henry Ferreyra; Klaus Stark; Claudia N von Strachwitz; Armin Wolf; Caroline Brandl; Guenther Rudolph; Matthias Olden; Margaux A Morrison; Denise J Morgan; Matthew Schu; Jeeyun Ahn; Giuliana Silvestri; Evangelia E Tsironi; Kyu Hyung Park; Lindsay A Farrer; Anton Orlin; Alexander Brucker; Mingyao Li; Christine A Curcio; Saddek Mohand-Said; Jose-Alain Sahel; Isabelle Audo; Mustapha Benchaboune; Angela J Cree; Christina A Rennie; Srinivas Goverdhan; Shira Hagbi-Levi; Peter Campochiaro; Nicholas Katsanis; Frank G Holz; Frederic Blond; Helene Blanche; Jean-Francois Deleuze; Barbara Truitt; Neal S Peachey; Stacy M Meuer; Chelsea E Myers; Emily L Moore; Ronald Klein; Michael A Hauser; Eric A Postel; Monique D Courtenay; Stephen G Schwartz; Jaclyn L Kovach; William K Scott; Gerald Liew; Ava G Tan; Bamini Gopinath; John C Merriam; R Theodore Smith; Jane C Khan; Humma Shahid; Anthony T Moore; J Allie McGrath; Renee Laux; Milam A Brantley; Anita Agarwal; Lebriz Ersoy; Albert Caramoy; Thomas Langmann; Nicole TM Saksens; Eiko K de Jong; Carel B Hoyng; Melinda S Cain; Andrea J Richardson; Tammy M Martin; John Blangero; Daniel E Weeks; Bal Dhillon; Cornelia M van Duijn; Kimberly F Doheny; Jane Romm; Caroline CW Klaver; Caroline Hayward; Michael B Gorin; Michael L Klein; Paul N Baird; Anneke den Hollander; Sascha Fauser; John RW Yates; Rando Allikmets; Jie Jin Wang; Debra A Schaumberg; Barbara EK Klein; Stephanie A Hagstrom; Itay Chowers; Andrew J Lotery; Thierry Leveillard; Kang Zhang; Murray H Brilliant; Alex W Hewitt; Anand Swaroop; Emily Y Chew; Margaret A Pericak-Vance; Margaret DeAngelis; Dwight Stambolian; Sudha K Iyengar; Bernhard HF Weber; Goncalo R Abecasis; Iris M Heid

Journal article

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

Andrea R Waksmunski, Michelle Grunin, Tyler G Kinzy, Robert P Igo, Jonathan L Haines, Jessica N Cooke Bailey, Lars G Fritsche, Wilmar Igl, Felix Grassmann, Sebanti Sengupta, Jennifer L Bragg-Gresham, Kathryn P Burdon, Scott J Hebbring, Cindy Wen, Mathias Gorski, Ivana K Kim, David Cho, Donald Zack, Eric Souied, Hendrik PN Scholl Show all

Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2019

DOI: 10.1167/iovs.19-27827

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University of Melbourne Researchers

Jamie Craig Author Ophthalmology Eye and Ear Hospital

Paul Baird Author Ophthalmology Eye and Ear Hospital

David Mackey Author Ophthalmology Eye and Ear Hospital

Robyn Guymer Author Ophthalmology Eye and Ear Hospital

Grants

Awarded by VSTP Training Grant

Awarded by National Institutes of Health National Center for Advancing Translational Science (NCATS)

Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

Awarded by NATIONAL EYE INSTITUTE

Funding Acknowledgements

Supported by Grants 1X01HG006934-01, R01 EY022310, the National Institutes of Health National Center for Advancing Translational Science (NCATS) Grant KL2TR000440 (JNCB), and the VSTP Training Grant T32EY007157-18 (MG).