Journal article
Pig endothelial protein C receptor is functionally compatible with the human protein C pathway
Evelyn J Salvaris, Christopher J Moran, Jean Christian Roussel, Nella Fisicaro, Simon C Robson, Peter J Cowan
XENOTRANSPLANTATION | WILEY | Published : 2019
DOI: 10.1111/xen.12557
Abstract
BACKGROUND: Endothelial protein C receptor (EPCR) plays an anticoagulant and anti-inflammatory role by promoting the activation of protein C by thrombin bound to thrombomodulin (TBM). Incompatibility between pig TBM and human/primate thrombin is thought to contribute to dysregulated coagulation in pig-to-primate organ xenografts, and expression of human TBM (hTBM) in pigs has shown benefit in preclinical models. However, it is not known whether there are incompatibilities-or molecular barriers-between endogenous pig EPCR (pEPCR) and transgenically expressed human TBM. AIM: To clone and express pEPCR, and determine its function in the human protein C pathway in vitro. METHODS: Pig endothelial..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
National Health and Medical Research Council, Grant/Award Number: 558408