Journal article

Osteocalcin and its forms across the lifespan in adult men

Cassandra Smith, Sarah Voisin, Ahmed Al Saedi, Steven Phu, Tara Brennan-Speranza, Lewan Parker, Nir Eynon, Danielle Hiam, Xu Yan, David Scott, Lauren C Blekkenhorst, Joshua R Lewis, Ego Seeman, Elizabeth Byrnes, Leon Flicker, Gustavo Duque, Bu B Yeap, Itamar Levinger

Bone | ELSEVIER SCIENCE INC | Published : 2019

Abstract

PURPOSE: Osteocalcin (OC), an osteoblast-specific secreted protein expressed by mature osteoblasts, is used in clinical practice and in research as a marker of bone turnover. The carboxylated (cOC) and undercarboxylated (ucOC) forms may have a different biological function but age-specific reference ranges for these components are not established. Given the different physiological roles, development of reference ranges may help to identify people at risk for bone disease. METHODS: Blood was collected in the morning after an overnight fast from 236 adult men (18 to 92 years old) free of diabetes, antiresorptive, warfarin or glucocorticoid use. Serum was analyzed for total osteocalcin (tOC) an..

View full abstract