Journal article

Towards Future T Cell-Mediated Influenza Vaccines

Thi Hoang Oanh Nguyen, Marios Koutsakos, Emma Grant, Peter Doherty, Katherine Kedzierska

Infectious Diseases and Translational Medicine | International Biological and Medical Journals Publishing House Co., Limited | Published : 2016

Abstract

Influenza A virus infections (IAVs) impact significantly on global health, being particularly problematic in children, the elderly, pregnant women, indigenous populations and people with co-morbidities. Antibody-based vaccines require annual administration to combat rapidly acquired mutations modifying the surface haemagglutinin (HA) and neuraminidase (NA) glycoproteins. Conversely, influenza-specific CD8+ T cell responses directed at peptides derived from the more conserved internal virus proteins are known to be protective, suggesting that T cell-based vaccines may provide long-lasting cross-protection. This review outlines the importance of CD8+ T cell immunity to seasonal influenza and p..

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