Journal article

Predictors and Outcomes of Early Intubation in Infants Born at 28-36 Weeks of Gestation Receiving Noninvasive Respiratory Support

Calum T Roberts, Louise S Owen, Dag H Froisland, Lex W Doyle, Peter G Davis, Brett J Manley

The Journal of Pediatrics | MOSBY-ELSEVIER | Published : 2020

Abstract

OBJECTIVE: To identify predictors and outcomes of early intubation in preterm infants with respiratory distress, and predictors of need for brief respiratory support (≤1 day). STUDY DESIGN: Secondary analysis of data from a randomized trial comparing nasal high-flow with continuous positive airway pressure as primary respiratory support in preterm infants born at 28-36 weeks of gestation. Intubation was assessed within 72 hours of randomization. RESULTS: There were 564 included infants with a mean (SD) gestational age of 32.0 (2.2) weeks and birth weight 1744 (589) g; 76 infants (13.5%) received early intubation. On multivariable analysis, lower gestational age and higher pre-randomization f..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Awarded by Medical Research Future Fund (Australia) Next Generation Clinical Researchers Career Development Fellowship


Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship


Funding Acknowledgements

Supported by he National Health and Medical Research Council (NHMRC), Australia (No. 1079089, 1060733, and 1153176). C.R. is supported by the Monash University Kathleen Tinsley Research Fellowship. B.M. is supported by a Medical Research Future Fund (Australia) Next Generation Clinical Researchers Career Development Fellowship (MRF1159225). L.O. is supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship (No. 1159444). P.D. and C.R. have received travel support from Fisher and Paykel. The other authors declare no conflicts of interest.