Journal article

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

Carolina Gubert, Geraldine Kong, Thibault Renoir, Anthony J Hannan

Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020


The last decade has witnessed an exponentially growing interest in gut microbiota and the gut-brain axis in health and disease. Accumulating evidence from preclinical and clinical research indicate that gut microbiota, and their associated microbiomes, may influence pathogenic processes and thus the onset and progression of various diseases, including neurological and psychiatric disorders. In fact, gut dysbiosis (microbiota dysregulation) has been associated with a range of neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's and motor neuron disease, as well as multiple sclerosis. The gut microbiota constitutes a dynamic microbial system constantly challenged by man..

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Funding Acknowledgements

CG is recipient of a Post-Doctoral Fellowship (PDE - Pos Doutorado no Exterior) from CNPq - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, of the Ministry of Science, Technology, Innovation, Communication of Brazil and a University of Melbourne Early Career Researcher Award. TR is an NHMRC Dementia Fellow. AJH is an NHMRC Principal Research Fellow and is also supported by NHMRC Project Grants, an ARC Discovery Project and the DHB Foundation, Equity Trustees.