Journal article

Comparable effects of nicotine in smokers and nonsmokers on a prospective memory task

Jennifer M Rusted, Steven Trawley

Neuropsychopharmacology | NATURE PUBLISHING GROUP | Published : 2006


In a double-blind placebo-controlled study, we examined the effect of nicotine, a cholinergic agonist, on performance of a prospective memory (ProM) task in young adult volunteers. Volunteers were required to complete an ongoing lexical decision task while maintaining the ProM task (responding with a different button press to items containing particular target letters). Half of the volunteers were smokers, half were nonsmokers. Half of each group received a single dose (1 mg) of nicotine nasal spray before completing the task; the remaining volunteers received a matched inactive placebo spray. Nicotine improved performance on the ProM task when volunteers were able to devote resources to tha..

View full abstract