Clobazam in the treatment of epilepsy.
C Kilpatrick, R Bury, R Fullinfaw, R Moulds
Clinical and experimental neurology | Published : 1987
Clobazam, a 1,5-benzodiazepine, is a potent anticonvulsant but the development of tolerance limits its use. It has been suggested that low dose clobazam may prevent or delay the onset of tolerance. This study aimed to assess, by an open trial, the anticonvulsant activity of low dose clobazam in 11 adult patients with frequent intractable seizures. Serum clobazam and N-desmethylclobazam levels were assayed and correlated with clinical effect, adverse effects, drug dose and the development of tolerance. Clobazam was given in addition to conventional antiepileptic therapy, beginning with a dose of 20 mg at night. A 50% or greater reduction in the frequency of seizures was noted, at least transi..View full abstract